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Personal and family history of seizures and measles immunizaton; AAP Committee on Infectious Diseases

A recent analysis of reports of reactions following measles immunization has revealed that children who had seizures following measles vaccine were more likely to have a personal history of seizures or a history of seizures in siblings or parents than vaccinees who had non-neurologic reactions associated with immunization.¹ These seizures usually are associated with fever and occur 5-11 days post immunization when febrile reactions to Live Measles Vaccine (LMV) are most common; approximately 5-15 percent of vaccinees have elevated temperature during this time. The seizures resemble simple febrile seizures which are common in the fifteen month old children for whom LMV adminstrtion is recommended and are rarely associated with any sequelae. In one study, the vast majority of children who had seizures following LMV had temperature elevations and about half were associated with intercurrent infections.²